What can I do myself for menopausal symptoms?
Exercise has been shown to reduce menopausal symptoms
- Alcohol: Keep to moderate amounts because alcohol may trigger flushes
- Healthy Diet
- Relaxation – eg. yoga or mindfulness
- Alternative remedies – although trials into red clover and black cohash have been disappointing. Vitamin E may help a little.
What are the best treatments available?
There are two main prescribed treatment options for hot flushes:
- MHT (Menopausal Hormone Therapy that used to be called HRT).
- SSRI’s (serotonin reuptake inhibitors) are prescribed at low doses and reduces hot flushes by affecting the chemical messages involved in the nervous system’s temperature regulating system.
MHT consists of Oestrogen to make you feel better, and a progestogen (progesterone) to protect the Uterus from The Oestrogen. Hormonal therapy is generally more effective than SSRIs.
Oestrogen given topically (eg. via an applicator) often helps vaginal and/or bladder symptoms.
The combined contraceptive pill ‘may help to improve some of the symptoms of the menopause’4 whist providing good contraception. The dose of Oestrogen in ‘The pill’ is around 5 times higher than in MHT and therefore helps to alleviate symptoms. The old wives’ tale says that women in their late 40’s should not take the pill. In fact, the contraceptive pill is a safe choice for many peri-menopausal women.
Many women try alternative therapies. The doctor will be happy to discuss these with you. You may wish to look at the following impartial Australian Menopause Society bulletin on complementary and herbal therapies. The NICE guideline 2015 does state that there is some evidence that black Cohash may help.
Does MHT work?
There is no question that Menopausal Hormone Therapy can be of huge benefit for women with troublesome hot flushes or sweats. Recent UK, European, US and Australian guidlines all conclude that hormone therapy is generally the most effective treatment for typical menopausal symptoms.
Hormone therapy can also improve mood. The possibility of improved mood with MHT is something that goes back to the 1990’s and then fell out of favour. It’s good news that the benefit of hormonal therapy on mood has resurfaced. Doctors can once again ‘Consider MHT to alleviate low mood due to menopause.’³
The 2015 Endocrine society guideline states that Estrogen Therapy improves flushes, genitourinary symptoms, sleep disturbance, menopause-associated anxiety and depressive symptoms, and joint pains.
The symptoms most likely to respond to hormone therapy are flushes and genital symptoms, but it’s great news that it may also help sleep and mood.
What types of Oestrogen are found in MHT?
Oestrogen in MHT is generally in the form of Oestradiol.
Oestrogen comes in the form of tablets, patches or gel. There may be advantages to the patches or gel over the tablets. There are three patches available in Australia which are applied either weekly or twice weekly.
The Gel is applied every day and is useful in women who have concerns over the patch sticking. There is only one official dose of gel in Australia which may be considered a little limiting but Oestrogen absorption may be altered by changing how the gel is applied.
What types of Progesterone are there?
Progesterone has the very important job to do, namely to stop the uterus from being stimulated by Oestrogen. Oestrogen used on its own may otherwise cause Cancer of The Uterus.
Progesterone is commonly in the form of Norethisterone, with Dydrogesterone & Drospironone being somewhat more recent additions. Women who have had a hysterectomy do not require progestogen.
What is Micronised Progesterone?
Micronised Progesterone was approved by The TGA in 2016. Note that The TGA do not approve micronised progesterone that has been compounded.
There is increasing interest in Micronised Progesterone in women:
- Who experience progestogenic side effects such as mood disturbance.
- Who are at risk of cardiovascular disease.
There is debate regarding the dose of micronised progestogen that is required to ‘protect’ the uterus. A dose of 200mg is taken as 2 x 100mg capsules at night. A lower 100mg dose may be considered with lower doses of oestrogen.
Is MHT Safe?
MHT (also called HRT) is very safe in the majority of women and the Safety of MHT should be emphasized. Women may remember the ‘HRT scare’ of 2002. The scare was caused by The WHI study. It’s been shown time and time again that MHT is safe for women in their 40’s and 50’s. Even the WHI investigators themselves recently stated in a highly esteeemed medical journal (NEJM) that these WHI studies are ‘now being used inappropriately in making decisions about treatment for women in their 40s and 50s who have distressing vasomotor symptoms.’
A recent major review of MHT & cardiovascular risk² showed an overall small reduced cardiovascular risk in women taking MHT under the age of 60 for less than 10 years. Overall, you wouldn’t take MHT to prevent cardiovascular disease but the studies are very reassuring. Another major review³ is even more reassuring and states that ‘MHT does not increase cardiovascular disease when started before age 60.’
There is a small increased risk of Venous thrombosis with oral MHT (around 1 per 1000 women taking MHT per year) and this risk is highest in the first year of use but is also ongoing. The metabolism of oral oestrogen by the liver causes an increase in clotting fators.
There is no increased risk of blood clots with MHT patches.³
Now let’s look at breast cancer and MHT.
What are the risks of breast cancer with MHT?
There is an increased risk of breast cancer in older women with long term use. Take 1000 women taking MHT for 10 years: There are an extra 24 cases of breast cancer (after 5 years use there are 6 extra cases). Any increased risk occurs during treatment and ‘returns to baseline after stopping.’³
Note that the oestrogen-only MHT (after a hysterectomy) has a much smaller breast cancer risk (around 6 extra cases in 1000 women after 10 years use).
The breast cancer risk with medium to long term use needs to be discussed. A small number of women experience long term flushes, have considered or tried other treatment, accept these risks and take MHT long term.
What other types of MHT are available?
®Tibolone is a synthetic ‘progestin’ that has similar hormonal effects to HRT.
A new class of medication is called a ’tissue-selective oestrogen complex’ and allows the uterus to be protected without taking a progestogen. This can be helpful for women who experience side effects of progestogens, for example who experience breast tenderness.
The Progesten Intra Uterine Device provides the progesterone needed to protect the uterus, allowing you to take ‘only’ the oestrogen.
In a nutshell, there are stacks of options without needing to look at so-called ‘bio-identical hormones’ that the mainstream menopause & medical societies do not generally endorse.
How and when is MHT Stopped?
Figures show that half of women decide to stop HRT within 12 months, and two thirds within two years.
If and when the hot flushes return and are severe then the HRT can be restarted – and later gradually reduced in dose.
- The menopause clinic isn’t just about Hormones!
- Bone density reduces slowly because of the lower Oestrogen levels. Osteoporosis is very common with increasing age after the menopause. A bone density scan is recommended where there are risk factors for osteoporosis. Exercise, calcium & Vitamin D help reduce bone loss, and exercise reduces risk of falls.
- There’s an increased risk of cardiovascular disease in post menopausal women caused by the drop in oestrogen levels. Also, high Blood Pressure is more common in women than men over the age of around 45. Keep an eye on blood cholesterol / lipids as required.
- Cancer Screening – ongoing screening for cervical cancer, and screening for breast & bowel cancer.
I need contraception and treatment for the menopause at the same time
There’s no single solution here but the hormonal options include:
- MHT (estrogen-only) with the Progestogen Intrauterine device.
- MHT (combined) with the progesterone-oral contraceptive pill.
- The combined oral contraceptive pill (COCP) on its own may also help menopausal symptoms.
The combination of MHT with the progestogen-only contraceptive pill would involve taking, well, two different pills per day. A trial of the combined contraceptive pill is the most common scenario for women who don’t already have Intrauterine device or implant in place.
Women attending a menopause clinic naturally tend to focus on their menopausal symptoms rather than contraceptive requirements. Unless your partner has had a vasectomy then you will need to consider what contraception to use.
I’ve heard that Testosterone can help
Testosterone levels are highest at around the age of 20 and gradually decline after that. At the age of 40, testosterone levels are half of what they were at the age of 20. Testosterone levels fall abruptly after the ovaries are removed by surgery to the extent that symptoms are more likely.
There is evidence that low dose testosterone therapy may help women who:
- Have symptoms of low Androgen. For example, low sex drive & fatigue.
- Have no other explanation for the symptoms.
- Have confirmed low Testosterone levels on two blood tests.
- Have no other cause for low testosterone (eg the contraceptive pill).
Pharmaceutical-grade Testosterone therapy in women is available as a patch from Western Australia. The blood levels rise to the upper level of the normal range. Side effects are rare. Women who have had surgery to remove both ovaries are most likely to benefit.
The following terminology is used in this discussion:
- rBHT: Regulated Body identical Menopause Hormone Therapy – available from a standard pharmacy on prescription. This form of MHT offers some benefits over convential MHT – such as micronised Progesterone or transdermal Oestrogen. All evidence-based and regulated with plenty of options.
- cMHT: Compounded Menopause Hormone Therapy, also known as Bioidentical Hormones – available from a compounding pharmacy. Compounding pharmacies make products that are not made by pharmaceutical companies as a branded product.
Bioidentical hormones (cMHT) are not fully regulated whereas rBHT is fully regulated. By regulated we mean checks on safety.
Does it matter that cMHT is not regulated or approved by Australia’s Therapeutic Goods Administration (TGA)? Consider that compounded MHT is also not approved by The European Medicines Agency or The American safety agency. Have the world’s regulators of medical products have got together to ban something that is good for us? Do you believe in conspiracies? Let’s be honest – regulation is really boring, and no-one likes to be told what they can or can’t take. However, The International menopause society advised that cMHT is not recommended because of lack of:
- rigorous safety and efficacy testing
- batch standardisation
- purity measures.
Being honest, this is a decision for women to make but you should go into this with your eyes open and be aware that all major Australian and international menopause guidelines do not recommend Bioidentical hormone therapy. You’ll also have to find a doctor willing to prescribe compounded MHT which will be less likely in the future because AHPRA (that regulate doctors) are currently looking into the regulation of doctors ‘who practice unconvential medicine.’
In summary, there over 60 forms of MHT that are regulated by The TGA, including several bio-identical hormones.
An Endocrine Society Scientific Statement in 2016 put out that there is ‘no rationale for the routine prescribing of unregulated, untested, and potentially harmful custom-compounded bioidentical hormone therapies.’ Do flick down the above reference – if only to appreciate the amount of expertise and thinking that goes into the strongly-worded statement. There are 254 scientific references appended!
I hear a lot of conflicting information about the menopause. Where Else can I get reliable information?
Yes, there’s a lot of conflicting information! Fortunately, though, there are very reliable sources of information out there. The first two of these links are Australian Organisations, and the third is international:
Australian Menopause Society
International Menopause Society